Assay Detail
Binding
CHEMBL3787807
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant Candida albicans beta carbonic anhydrase NCE103 expressed in Escherichia coli preincubated for 15 mins by stopped-flow CO2 hydration assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Candida albicans |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Carbonic anhydrase (CHEMBL5337) ↗| Type | SINGLE PROTEIN |
| Organism | Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) |
Publication
Isatin analogs as novel inhibitors of Candida spp. β-carbonic anhydrase enzymes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 24 | 7.06 | 7.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3785289 | — | — | 1 | 7.66 |
| CHEMBL3765353 | — | — | 1 | 7.47 |
| CHEMBL3785846 | — | — | 1 | 7.45 |
| CHEMBL3787255 | — | — | 1 | 7.27 |
| CHEMBL3787586 | — | — | 1 | 7.26 |
| CHEMBL3785591 | — | — | 1 | 7.21 |
| CHEMBL3786965 | — | — | 1 | 7.18 |
| CHEMBL3785209 | — | — | 1 | 7.12 |
| CHEMBL3786969 | — | — | 1 | 7.10 |
| CHEMBL3787472 | — | — | 1 | 7.08 |
| CHEMBL3785654 | — | — | 1 | 7.08 |
| CHEMBL3786724 | — | — | 1 | 7.07 |
| CHEMBL1369708 | — | — | 1 | 7.06 |
| CHEMBL3786477 | — | — | 1 | 7.06 |
| CHEMBL3787489 | — | — | 1 | 7.04 |
| CHEMBL3785467 | — | — | 1 | 7.01 |
| CHEMBL3787222 | — | — | 1 | 6.89 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 6.88 |
| CHEMBL3785153 | — | — | 1 | 6.87 |
| CHEMBL3785735 | — | — | 1 | 6.86 |
| CHEMBL3786062 | — | — | 1 | 6.81 |
| CHEMBL3633555 | — | — | 1 | 6.80 |
| CHEMBL3785827 | — | — | 1 | 6.75 |
| CHEMBL3787148 | — | — | 1 | 6.53 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3785289 | — | Ki | = | 21.7 | nM | 7.66 |
| CHEMBL3765353 | — | Ki | = | 34.1 | nM | 7.47 |
| CHEMBL3785846 | — | Ki | = | 35.7 | nM | 7.45 |
| CHEMBL3787255 | — | Ki | = | 53.6 | nM | 7.27 |
| CHEMBL3787586 | — | Ki | = | 54.8 | nM | 7.26 |
| CHEMBL3785591 | — | Ki | = | 61.3 | nM | 7.21 |
| CHEMBL3786965 | — | Ki | = | 65.7 | nM | 7.18 |
| CHEMBL3785209 | — | Ki | = | 75.9 | nM | 7.12 |
| CHEMBL3786969 | — | Ki | = | 79.3 | nM | 7.10 |
| CHEMBL3787472 | — | Ki | = | 83.3 | nM | 7.08 |
| CHEMBL3785654 | — | Ki | = | 84.1 | nM | 7.08 |
| CHEMBL3786724 | — | Ki | = | 85.2 | nM | 7.07 |
| CHEMBL1369708 | — | Ki | = | 86.5 | nM | 7.06 |
| CHEMBL3786477 | — | Ki | = | 88.0 | nM | 7.06 |
| CHEMBL3787489 | — | Ki | = | 91.5 | nM | 7.04 |
| CHEMBL3785467 | — | Ki | = | 98.1 | nM | 7.01 |
| CHEMBL3787222 | — | Ki | = | 128.0 | nM | 6.89 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 132.0 | nM | 6.88 |
| CHEMBL3785153 | — | Ki | = | 136.0 | nM | 6.87 |
| CHEMBL3785735 | — | Ki | = | 139.0 | nM | 6.86 |
| CHEMBL3786062 | — | Ki | = | 156.0 | nM | 6.81 |
| CHEMBL3633555 | — | Ki | = | 157.0 | nM | 6.80 |
| CHEMBL3785827 | — | Ki | = | 178.0 | nM | 6.75 |
| CHEMBL3787148 | — | Ki | = | 295.0 | nM | 6.53 |