Assay Detail
Binding
CHEMBL3787813
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human PTP-1B expressed in Escherichia coli TB1 using p-nitrophenyl phosphate as substrate
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Tyrosine-protein phosphatase non-receptor type 1 (CHEMBL335) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
In vitro and in silico PTP-1B inhibition and in vivo antidiabetic activity of semisynthetic moronic acid derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.99 | 5.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3786595 | — | — | 1 | 5.12 |
| CHEMBL3787288 | — | — | 1 | 4.97 |
| CHEMBL472646 | MORONIC ACID | — | 1 | 4.88 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3786595 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL3787288 | — | IC50 | = | 10800.0 | nM | 4.97 |
| CHEMBL472646 | MORONIC ACID | IC50 | = | 13200.0 | nM | 4.88 |