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Assay Detail

CHEMBL3787941

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Functional
Antiproliferative activity against human A375 cells assessed as cell growth inhibition after 96 hrs by MTT assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type A-375
Confidence 1 — Organism
Curated By Autocuration

Target

A-375 (CHEMBL613859)
Type CELL-LINE
Organism Homo sapiens

Publication

New imidazoquinoxaline derivatives: Synthesis, biological evaluation on melanoma, effect on tubulin polymerization and structure-activity relationships.
Zghaib Z, Guichou JF, Vappiani J, Bec N, Hadj-Kaddour K, Vincent LA, Paniagua-Gayraud S, Larroque C, Moarbess G, Cuq P, Kassab I, Deleuze-Masquéfa C, Diab-Assaf M, Bonnet PA.
Bioorg Med Chem (2016) 24 : 2433 -2440
PubMed 27094151 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 6.29 8.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL107 COLCHICINE 4.0 1 8.00
CHEMBL3787643 1 7.11
CHEMBL557421 1 6.70
CHEMBL3786292 1 6.70
CHEMBL3786984 1 6.66
CHEMBL3785682 1 6.52
CHEMBL550940 1 6.43
CHEMBL3787470 1 5.92
CHEMBL555515 1 5.90
CHEMBL3785973 1 5.82
CHEMBL3787056 1 5.75
CHEMBL3785389 1 5.64
CHEMBL3787625 1 5.62
CHEMBL3785769 1 5.23
CHEMBL549655 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL107 COLCHICINE IC50 = 10.0 nM 8.00
CHEMBL3787643 IC50 = 77.0 nM 7.11
CHEMBL557421 IC50 = 200.0 nM 6.70
CHEMBL3786292 IC50 = 200.0 nM 6.70
CHEMBL3786984 IC50 = 220.0 nM 6.66
CHEMBL3785682 IC50 = 300.0 nM 6.52
CHEMBL550940 IC50 = 370.0 nM 6.43
CHEMBL3787470 IC50 = 1200.0 nM 5.92
CHEMBL555515 IC50 = 1250.0 nM 5.90
CHEMBL3785973 IC50 = 1500.0 nM 5.82
CHEMBL3787056 IC50 = 1800.0 nM 5.75
CHEMBL3785389 IC50 = 2300.0 nM 5.64
CHEMBL3787625 IC50 = 2400.0 nM 5.62
CHEMBL3785769 IC50 = 5900.0 nM 5.23
CHEMBL549655 IC50 = 122000.0 nM -