Assay Detail
Functional
CHEMBL3788085
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Antiviral activity against wild type HIV1 3B infected in human MT4 cells assessed as cell viability after 4 days by MTT assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Design, synthesis and evaluation of novel HIV-1 NNRTIs with dual structural conformations targeting the entrance channel of the NNRTI binding pocket.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 25 | 6.54 | 8.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL308954 | ETRAVIRINE | 4.0 | 1 | 8.41 |
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 8.27 |
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 8.15 |
| CHEMBL929 | DELAVIRDINE MESYLATE | 4.0 | 1 | 7.57 |
| CHEMBL3786091 | — | — | 1 | 6.96 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 6.55 |
| CHEMBL3787053 | — | — | 1 | 6.11 |
| CHEMBL3786521 | — | — | 1 | 6.10 |
| CHEMBL3787530 | — | — | 1 | 6.09 |
| CHEMBL18314 | — | — | 1 | 5.60 |
| CHEMBL3786888 | — | — | 1 | 4.50 |
| CHEMBL1460 | DIDANOSINE | 4.0 | 1 | 4.12 |
| CHEMBL3785979 | — | — | 1 | - |
| CHEMBL3785606 | — | — | 1 | - |
| CHEMBL3785710 | — | — | 1 | - |
| CHEMBL3786238 | — | — | 1 | - |
| CHEMBL3785272 | — | — | 1 | - |
| CHEMBL3787427 | — | — | 1 | - |
| CHEMBL3786801 | — | — | 1 | - |
| CHEMBL3785380 | — | — | 1 | - |
| CHEMBL3785698 | — | — | 1 | - |
| CHEMBL3785490 | — | — | 1 | - |
| CHEMBL3786825 | — | — | 1 | - |
| CHEMBL3785620 | — | — | 1 | - |
| CHEMBL3786392 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL308954 | ETRAVIRINE | EC50 | = | 3.9 | nM | 8.41 |
| CHEMBL223228 | EFAVIRENZ | EC50 | = | 5.4 | nM | 8.27 |
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL929 | DELAVIRDINE MESYLATE | EC50 | = | 27.0 | nM | 7.57 |
| CHEMBL3786091 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL57 | NEVIRAPINE | EC50 | = | 280.0 | nM | 6.55 |
| CHEMBL3787053 | — | EC50 | = | 780.0 | nM | 6.11 |
| CHEMBL3786521 | — | EC50 | = | 790.0 | nM | 6.10 |
| CHEMBL3787530 | — | EC50 | = | 820.0 | nM | 6.09 |
| CHEMBL18314 | — | EC50 | = | 2530.0 | nM | 5.60 |
| CHEMBL3786888 | — | EC50 | = | 31360.0 | nM | 4.50 |
| CHEMBL1460 | DIDANOSINE | EC50 | = | 75990.0 | nM | 4.12 |
| CHEMBL3785979 | — | EC50 | > | 2890.0 | nM | - |
| CHEMBL3785606 | — | EC50 | > | 2730.0 | nM | - |
| CHEMBL3785710 | — | EC50 | > | 3150.0 | nM | - |
| CHEMBL3786238 | — | EC50 | > | 17360.0 | nM | - |
| CHEMBL3785272 | — | EC50 | > | 8530.0 | nM | - |
| CHEMBL3787427 | — | EC50 | > | 24090.0 | nM | - |
| CHEMBL3786801 | — | EC50 | >= | 1620.0 | nM | - |
| CHEMBL3785380 | — | EC50 | > | 48160.0 | nM | - |
| CHEMBL3785698 | — | EC50 | > | 27090.0 | nM | - |
| CHEMBL3785490 | — | EC50 | > | 50950.0 | nM | - |
| CHEMBL3786825 | — | EC50 | > | 12590.0 | nM | - |
| CHEMBL3785620 | — | EC50 | > | 5380.0 | nM | - |
| CHEMBL3786392 | — | EC50 | > | 25830.0 | nM | - |