Assay Detail
Functional
CHEMBL3788086
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 RES056 harboring reverse transcriptase K103N/YI81C double mutant infected in human MT4 cells assessed as cell viability after 4 days by MTT assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Design, synthesis and evaluation of novel HIV-1 NNRTIs with dual structural conformations targeting the entrance channel of the NNRTI binding pocket.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 12 | 6.89 | 7.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 7.77 |
| CHEMBL308954 | ETRAVIRINE | 4.0 | 1 | 7.47 |
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 6.65 |
| CHEMBL3786091 | — | — | 1 | 5.66 |
| CHEMBL929 | DELAVIRDINE MESYLATE | 4.0 | 1 | - |
| CHEMBL3787530 | — | — | 1 | - |
| CHEMBL3786521 | — | — | 1 | - |
| CHEMBL3786888 | — | — | 1 | - |
| CHEMBL3787427 | — | — | 1 | - |
| CHEMBL3787053 | — | — | 1 | - |
| CHEMBL3786801 | — | — | 1 | - |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL308954 | ETRAVIRINE | EC50 | = | 34.0 | nM | 7.47 |
| CHEMBL223228 | EFAVIRENZ | EC50 | = | 225.0 | nM | 6.65 |
| CHEMBL3786091 | — | EC50 | = | 2180.0 | nM | 5.66 |
| CHEMBL929 | DELAVIRDINE MESYLATE | EC50 | > | 28230.0 | nM | - |
| CHEMBL3787530 | — | EC50 | > | 2960.0 | nM | - |
| CHEMBL3786521 | — | EC50 | > | 3280.0 | nM | - |
| CHEMBL3786888 | — | EC50 | > | 274000.0 | nM | - |
| CHEMBL3787427 | — | EC50 | > | 24090.0 | nM | - |
| CHEMBL3787053 | — | EC50 | > | 5980.0 | nM | - |
| CHEMBL3786801 | — | EC50 | > | 6670.0 | nM | - |
| CHEMBL57 | NEVIRAPINE | EC50 | > | 15020.0 | nM | - |