Assay Detail
Binding
CHEMBL3788438
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Inhibition of thrombin (unknown origin)
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of AZD8165 a clinical candidate from a novel series of neutral thrombin inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.61 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3787587 | — | — | 1 | 8.40 |
| CHEMBL3786896 | AZD-8165 | 1.0 | 1 | 6.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3787587 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3786896 | AZD-8165 | IC50 | = | 150.0 | nM | 6.82 |