Assay Detail
Binding
CHEMBL3789015
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at rat mGlu3 receptor expressed in HEK293 cells by [35S]GTP-gamma binding assay
9
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Metabotropic glutamate receptor 3 (CHEMBL3067) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
New 4-Functionalized Glutamate Analogues Are Selective Agonists at Metabotropic Glutamate Receptor Subtype 2 or Selective Agonists at Metabotropic Glutamate Receptor Group III.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 7.23 | 7.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL575060 | GLUTAMIC ACID | 3.0 | 2 | 7.24 |
| CHEMBL2312685 | — | — | 1 | - |
| CHEMBL2312684 | — | — | 1 | - |
| CHEMBL2312682 | — | — | 1 | - |
| CHEMBL2312403 | — | — | 1 | - |
| CHEMBL2312683 | — | — | 1 | - |
| CHEMBL482081 | — | — | 1 | - |
| CHEMBL479797 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL575060 | GLUTAMIC ACID | EC50 | = | 57.54 | nM | 7.24 |
| CHEMBL575060 | GLUTAMIC ACID | EC50 | = | 60.0 | nM | 7.22 |
| CHEMBL2312685 | — | EC50 | > | 1000000.0 | nM | - |
| CHEMBL2312684 | — | EC50 | > | 1000000.0 | nM | - |
| CHEMBL2312682 | — | EC50 | > | 1000000.0 | nM | - |
| CHEMBL2312403 | — | EC50 | > | 1000000.0 | nM | - |
| CHEMBL2312683 | — | EC50 | > | 1000000.0 | nM | - |
| CHEMBL482081 | — | EC50 | = | 348000.0 | nM | - |
| CHEMBL479797 | — | EC50 | > | 1000000.0 | nM | - |