Assay Detail
Functional
CHEMBL3789083
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Cytotoxicity against human HCT116 cells after 48 hrs by MTT assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and screening of ursolic acid-benzylidine derivatives as potential anti-cancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 5.23 | 6.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3786587 | — | — | 1 | 6.28 |
| CHEMBL3786131 | — | — | 1 | 6.19 |
| CHEMBL3786641 | — | — | 1 | 5.68 |
| CHEMBL3785858 | — | — | 1 | 5.68 |
| CHEMBL487887 | URSONIC ACID | — | 1 | 5.64 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 5.64 |
| CHEMBL3785146 | — | — | 1 | 5.39 |
| CHEMBL3785919 | — | — | 1 | 5.30 |
| CHEMBL3785790 | — | — | 1 | 5.30 |
| CHEMBL3786720 | — | — | 1 | 4.92 |
| CHEMBL3786243 | — | — | 1 | 4.92 |
| CHEMBL3787679 | — | — | 1 | 4.85 |
| CHEMBL3785352 | — | — | 1 | 4.82 |
| CHEMBL3786933 | — | — | 1 | 4.82 |
| CHEMBL3787355 | — | — | 1 | 4.64 |
| CHEMBL3785992 | — | — | 1 | 4.50 |
| CHEMBL169 | URSOLIC ACID | 2.0 | 1 | 4.38 |
| CHEMBL3785444 | — | — | 1 | - |
| CHEMBL3785587 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3786587 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL3786131 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL3786641 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL3785858 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL487887 | URSONIC ACID | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL3785146 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL3785919 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL3785790 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL3786720 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL3786243 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL3787679 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL3785352 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL3786933 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL3787355 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL3785992 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL169 | URSOLIC ACID | IC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL3785444 | — | IC50 | < | 900.0 | nM | - |
| CHEMBL3785587 | — | IC50 | < | 100.0 | nM | - |