Assay Detail
Binding
CHEMBL3789204
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of KDM5B in human PC9 cells assessed as reduction in demethylation of H3K4me3 after 120 hrs by AlphaLisa assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | PC-9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Recent Progress in Histone Demethylase Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 6.52 | 6.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3785583 | — | — | 1 | 6.75 |
| CHEMBL3785443 | — | — | 1 | 6.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3785583 | — | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL3785443 | — | EC50 | = | 530.0 | nM | 6.28 |