Lysine-specific demethylase 5B · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt Q9UGL1. Use UniProt Q9UGL1 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q9UGL1 as the stable identity anchor, then attach disease evidence before program review.
Lysine-specific demethylase 5B
Review this target as Lysine-specific demethylase 5B, mapped to UniProt Q9UGL1. Sequence length is 1544 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Lysine-specific demethylase 5B as ChEMBL target CHEMBL3774295, mapped to UniProt Q9UGL1. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Lysine-specific demethylase 5B |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q9UGL1 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Lysine-specific demethylase 5B |
| UniProt Accession | Q9UGL1 |
| Component Type | Protein |
| Sequence Length | 1544 aa |
Lysine-specific demethylase 5B
Review this target as Lysine-specific demethylase 5B, mapped to UniProt Q9UGL1. Sequence length is 1544 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4229271 | 9.22 | IC50 | 0.6 | Preclinical |
| CHEMBL4225358 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL4228292 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL4228806 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL4438830 | 9.0 | Ki | 1.0 | Preclinical |
| CHEMBL4567766 | 9.0 | Ki | 1.0 | Preclinical |
| CHEMBL4542928 | 8.87 | IC50 | 1.34 | Preclinical |
| CHEMBL3774537 | 8.7 | Ki | 2.0 | Preclinical |
| CHEMBL3786952 | 8.7 | IC50 | 2.0 | Preclinical |
| CHEMBL4226978 | 8.7 | IC50 | 2.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 74 | 398 | 6.5 |
| cell-based format | 51 | 177 | 6.5 |
| assay format | 4 | 195 | 6.9 |