Compound Detail
CHEMBL4228292
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Basic Information
| ChEMBL ID | CHEMBL4228292 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | TVFQMRCHDYLPNH-UHFFFAOYSA-N |
4
Targets
5
Activities
2
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
359.8
MW (Da)
3.21
ALogP
6
HBA
1
HBD
86.5
PSA (Ų)
0.73
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 9.0
EC50 1 meas. best 6.96
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Lysine-specific demethylase 5B CHEMBL3774295 | IC50 | 9.0 | 9.0 | 1.0 | 1 |
| Lysine-specific demethylase 5A CHEMBL2424504 | IC50 | 7.92 | 7.92 | 12.0 | 1 |
| Lysine-specific demethylase 4C CHEMBL6175 | IC50 | 7.42 | 7.42 | 38.0 | 1 |
| Lysine-specific demethylase 5A/5B CHEMBL4296073 | IC50 | 7.0 | 7.0 | 100.0 | 1 |
| Lysine-specific demethylase 5A/5B CHEMBL4296073 | EC50 | 6.96 | 6.96 | 110.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Lysine-specific demethylase 5B | IC50 | = | 1.0 | nM | 9.0 | Inhibition of KDM5B (unknown origin) preincubated with enzyme | 29627262 |
| Lysine-specific demethylase 5A | IC50 | = | 12.0 | nM | 7.92 | Inhibition of KDM5A (unknown origin) preincubated with enzyme | 29627262 |
| Lysine-specific demethylase 4C | IC50 | = | 38.0 | nM | 7.42 | Inhibition of KDM4C (unknown origin) preincubated with enzyme | 29627262 |
| Lysine-specific demethylase 5A/5B | IC50 | = | 100.0 | nM | 7.0 | Inhibition of KDM5A/KDM5B in human ZR-75-1 cells assessed as increase in H3K4me3... | - |
| Lysine-specific demethylase 5A/5B | EC50 | = | 110.0 | nM | 6.96 | Inhibition of KDM5A/KDM5B in human ZR-75-1 cells assessed as increase in H3K4me3... | 29627262 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 29627262 | 10.1016/j.bmcl.2018.03.083 | Lysine-specific demethylase 5A | 1 |
| 29627262 | 10.1016/j.bmcl.2018.03.083 | Lysine-specific demethylase 5B | 1 |
| 29627262 | 10.1016/j.bmcl.2018.03.083 | Lysine-specific demethylase 4C | 1 |
| 29627262 | 10.1016/j.bmcl.2018.03.083 | Lysine-specific demethylase 5A/5B | 1 |
Data from ChEMBL 36 via Core Engine