Assay Detail
Binding
CHEMBL3789211
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of KDM4C (1 to 349 residues) (unknown origin) expressed in Escherichia coli using biotinylated histone H3 as substrate preincubated for 10 mins followed by substrate addition measured after 10 mins by AlphaLisa assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Recent Progress in Histone Demethylase Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.00 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3786593 | — | — | 1 | 7.00 |
| CHEMBL3787547 | — | — | 1 | - |
| CHEMBL3786409 | — | — | 1 | - |
| CHEMBL3787669 | — | — | 1 | - |
| CHEMBL3787193 | — | — | 1 | - |
| CHEMBL3786239 | — | — | 1 | - |
| CHEMBL3786275 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3786593 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3787547 | — | IC50 | > | 2500.0 | nM | - |
| CHEMBL3786409 | — | IC50 | > | 2500.0 | nM | - |
| CHEMBL3787669 | — | IC50 | < | 100.0 | nM | - |
| CHEMBL3787193 | — | IC50 | < | 100.0 | nM | - |
| CHEMBL3786239 | — | IC50 | > | 2500.0 | nM | - |
| CHEMBL3786275 | — | IC50 | < | 250.0 | nM | - |