Assay Detail
Binding
CHEMBL3789353
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of mouse RIP1 in mouse L929 cells assessed as inhibition of TNF/zVAD.fmk induced necroptosis by Cell titer-Glo luminescence assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | L929 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Receptor-interacting serine/threonine-protein kinase 1 (CHEMBL3784911) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
DNA-Encoded Library Screening Identifies Benzo[b][1,4]oxazepin-4-ones as Highly Potent and Monoselective Receptor Interacting Protein 1 Kinase Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.80 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3109202 | — | — | 1 | 6.40 |
| CHEMBL3785703 | — | — | 1 | 5.50 |
| CHEMBL3786078 | — | — | 1 | 5.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3109202 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL3785703 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL3786078 | — | IC50 | = | 3200.0 | nM | 5.50 |