Assay Detail
Binding
CHEMBL3789400
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Inhibition of IGF-1 receptor (unknown origin)
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Insulin-like growth factor 1 receptor (CHEMBL1957) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of a 5-[3-phenyl-(2-cyclic-ether)-methylether]-4-aminopyrrolo[2,3-d]pyrimidine series of IGF-1R inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 6.50 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3786567 | — | — | 1 | 8.05 |
| CHEMBL3785273 | — | — | 1 | 7.22 |
| CHEMBL1614712 | — | — | 1 | 7.21 |
| CHEMBL3787614 | — | — | 1 | 7.10 |
| CHEMBL3786383 | — | — | 1 | 7.10 |
| CHEMBL3786793 | — | — | 1 | 6.96 |
| CHEMBL3787668 | — | — | 1 | 6.89 |
| CHEMBL3786598 | — | — | 1 | 6.80 |
| CHEMBL3786472 | — | — | 1 | 6.58 |
| CHEMBL3785927 | — | — | 1 | 6.51 |
| CHEMBL3786115 | — | — | 1 | 6.43 |
| CHEMBL3787112 | — | — | 1 | 6.38 |
| CHEMBL3785169 | — | — | 1 | 6.31 |
| CHEMBL3787399 | — | — | 1 | 6.26 |
| CHEMBL3786668 | — | — | 1 | 6.20 |
| CHEMBL3786564 | — | — | 1 | 6.08 |
| CHEMBL3787253 | — | — | 1 | 5.72 |
| CHEMBL3787579 | — | — | 1 | 5.70 |
| CHEMBL3785519 | — | — | 1 | 5.43 |
| CHEMBL3787474 | — | — | 1 | 5.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3786567 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL3785273 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL1614712 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL3787614 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL3786383 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL3786793 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL3787668 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL3786598 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL3786472 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL3785927 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL3786115 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL3787112 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL3785169 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL3787399 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL3786668 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL3786564 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL3787253 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL3787579 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL3785519 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL3787474 | — | IC50 | = | 7900.0 | nM | 5.10 |