Assay Detail
Binding
CHEMBL3789448
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of KDM5C in human U2OS cells assessed as reduction in demethylation of H3K4me3 after 20 hrs by Hoechst 33342 staining based immunofluorescence assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | U2OS |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Recent Progress in Histone Demethylase Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.00 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3787669 | — | — | 1 | 6.00 |
| CHEMBL3787193 | — | — | 1 | - |
| CHEMBL3786593 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3787669 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3787193 | — | IC50 | < | 1000.0 | nM | - |
| CHEMBL3786593 | — | IC50 | < | 1000.0 | nM | - |