Assay Detail
Functional
CHEMBL3789478
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Cytotoxicity against human U266 cells after 72 hrs by MTS assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | U-266 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and docking studies of novel dipeptidyl boronic acid proteasome inhibitors constructed from αα- and αβ-amino acids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 8.20 | 8.61 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3786484 | — | — | 1 | 8.61 |
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 8.24 |
| CHEMBL3785613 | — | — | 1 | 8.22 |
| CHEMBL3785681 | — | — | 1 | 8.10 |
| CHEMBL3787673 | — | — | 1 | 8.07 |
| CHEMBL3785317 | — | — | 1 | 7.94 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3786484 | — | IC50 | = | 2.48 | nM | 8.61 |
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 5.73 | nM | 8.24 |
| CHEMBL3785613 | — | IC50 | = | 6.04 | nM | 8.22 |
| CHEMBL3785681 | — | IC50 | = | 8.01 | nM | 8.10 |
| CHEMBL3787673 | — | IC50 | = | 8.51 | nM | 8.07 |
| CHEMBL3785317 | — | IC50 | = | 11.5 | nM | 7.94 |