Assay Detail
Functional
CHEMBL3789479
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Cytotoxicity against human RPMI8226 cells after 72 hrs by MTS assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | RPMI-8226 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and docking studies of novel dipeptidyl boronic acid proteasome inhibitors constructed from αα- and αβ-amino acids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 8.35 | 8.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3786484 | — | — | 1 | 8.64 |
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 8.41 |
| CHEMBL3785613 | — | — | 1 | 8.34 |
| CHEMBL3785681 | — | — | 1 | 8.34 |
| CHEMBL3787673 | — | — | 1 | 8.25 |
| CHEMBL3785317 | — | — | 1 | 8.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3786484 | — | IC50 | = | 2.29 | nM | 8.64 |
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 3.88 | nM | 8.41 |
| CHEMBL3785613 | — | IC50 | = | 4.56 | nM | 8.34 |
| CHEMBL3785681 | — | IC50 | = | 4.54 | nM | 8.34 |
| CHEMBL3787673 | — | IC50 | = | 5.61 | nM | 8.25 |
| CHEMBL3785317 | — | IC50 | = | 7.32 | nM | 8.13 |