Assay Detail
Binding
CHEMBL3789495
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Inhibition of wild type EGFR phosphorylation in human LoVo cells preincubated for 2 hrs followed by EGF stimulation measured after 30 mins by ELISA
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | LoVo |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Recent progress on third generation covalent EGFR inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.64 | 7.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3353411 | — | — | 1 | 7.48 |
| CHEMBL3353410 | OSIMERTINIB | 4.0 | 1 | 6.32 |
| CHEMBL3353412 | — | — | 1 | 6.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3353411 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL3353410 | OSIMERTINIB | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL3353412 | — | IC50 | = | 786.0 | nM | 6.11 |