Assay Detail
Binding
CHEMBL3789506
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of EGFR L858R/T790M double mutant in human NCI-H1975 cells assessed as suppression of cell proliferation
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | NCI-H1975 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Recent progress on third generation covalent EGFR inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.90 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3663929 | NAQUOTINIB | 3.0 | 1 | 8.10 |
| CHEMBL3786343 | OLMUTINIB | 4.0 | 1 | 8.00 |
| CHEMBL3787344 | NAZARTINIB | 2.0 | 1 | 7.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3663929 | NAQUOTINIB | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL3786343 | OLMUTINIB | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3787344 | NAZARTINIB | IC50 | = | 25.0 | nM | 7.60 |