Assay Detail
Binding
CHEMBL3789508
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of EGFR Del ex19 mutant in human HCC827 cells assessed as suppression of cell proliferation
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HCC827 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Recent progress on third generation covalent EGFR inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.03 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3663929 | NAQUOTINIB | 3.0 | 1 | 8.10 |
| CHEMBL3787344 | NAZARTINIB | 2.0 | 1 | 7.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3663929 | NAQUOTINIB | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL3787344 | NAZARTINIB | IC50 | = | 11.0 | nM | 7.96 |