Assay Detail
Functional
CHEMBL3789512
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Antiproliferative activity against B cells (unknown origin)
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Not specified |
| Cell Type | B-cell |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Approaching the active conformation of 1,3-diaminopyrimidine based covalent inhibitors of Bruton's tyrosine kinase for treatment of Rheumatoid arthritis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.70 | 8.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3301625 | SPEBRUTINIB | 2.0 | 1 | 8.48 |
| CHEMBL3785165 | — | — | 1 | 8.45 |
| CHEMBL3786656 | — | — | 1 | 8.23 |
| CHEMBL3787191 | — | — | 1 | 8.16 |
| CHEMBL3785329 | — | — | 1 | 7.86 |
| CHEMBL3786931 | — | — | 1 | 7.83 |
| CHEMBL3787055 | — | — | 1 | 7.71 |
| CHEMBL3787531 | — | — | 1 | 7.51 |
| CHEMBL3787615 | — | — | 1 | 7.19 |
| CHEMBL3787217 | — | — | 1 | 7.15 |
| CHEMBL3787671 | — | — | 1 | 6.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3301625 | SPEBRUTINIB | IC50 | = | 3.28 | nM | 8.48 |
| CHEMBL3785165 | — | IC50 | = | 3.55 | nM | 8.45 |
| CHEMBL3786656 | — | IC50 | = | 5.85 | nM | 8.23 |
| CHEMBL3787191 | — | IC50 | = | 6.84 | nM | 8.16 |
| CHEMBL3785329 | — | IC50 | = | 13.7 | nM | 7.86 |
| CHEMBL3786931 | — | IC50 | = | 14.9 | nM | 7.83 |
| CHEMBL3787055 | — | IC50 | = | 19.4 | nM | 7.71 |
| CHEMBL3787531 | — | IC50 | = | 30.6 | nM | 7.51 |
| CHEMBL3787615 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL3787217 | — | IC50 | = | 70.6 | nM | 7.15 |
| CHEMBL3787671 | — | IC50 | = | 818.4 | nM | 6.09 |