Assay Detail
Functional
CHEMBL3789660
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Cytotoxicity against human SJSA1 cells after 48 hrs by crystal violet staining based assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SJSA-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Derivatization of agelastatin A leading to bioactive analogs and a trifunctional probe.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.31 | 6.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1096256 | AGELASTATIN A | — | 1 | 6.36 |
| CHEMBL3787074 | — | — | 1 | 6.25 |
| CHEMBL3298663 | — | — | 1 | - |
| CHEMBL3787242 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1096256 | AGELASTATIN A | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL3787074 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL3298663 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL3787242 | — | IC50 | > | 1000.0 | nM | - |