Assay Detail
Functional
CHEMBL3789665
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Cytotoxicity against human CLL cells after 24 hrs by annexin-V/PI staining based flow cytometry in presence of fetal bovine serum
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CLL |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Derivatization of agelastatin A leading to bioactive analogs and a trifunctional probe.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.81 | 6.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1096256 | AGELASTATIN A | — | 1 | 6.03 |
| CHEMBL3787074 | — | — | 1 | 5.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1096256 | AGELASTATIN A | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL3787074 | — | IC50 | = | 2650.0 | nM | 5.58 |