Assay Detail
Binding
CHEMBL3789672
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Inhibition of IGF-1 receptor (unknown origin) in presence of [gamma33P]ATP
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Insulin-like growth factor 1 receptor (CHEMBL1957) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Optimisation of a 5-[3-phenyl-(2-cyclic-ether)-methyl-ether]-4-aminopyrrolopyrimidine series of IGF-1R inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 7.42 | 8.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3787360 | — | — | 1 | 8.37 |
| CHEMBL3786100 | — | — | 1 | 8.08 |
| CHEMBL3787636 | — | — | 1 | 8.03 |
| CHEMBL3785376 | — | — | 1 | 8.02 |
| CHEMBL3785995 | — | — | 1 | 7.92 |
| CHEMBL3785951 | — | — | 1 | 7.92 |
| CHEMBL3787271 | — | — | 1 | 7.89 |
| CHEMBL1091644 | LINSITINIB | 3.0 | 1 | 7.85 |
| CHEMBL3786167 | — | — | 1 | 7.80 |
| CHEMBL3787436 | — | — | 1 | 7.80 |
| CHEMBL3787567 | — | — | 1 | 7.48 |
| CHEMBL3785500 | — | — | 1 | 7.34 |
| CHEMBL3786558 | — | — | 1 | 7.33 |
| CHEMBL3786025 | — | — | 1 | 7.27 |
| CHEMBL1614712 | — | — | 1 | 7.21 |
| CHEMBL3786149 | — | — | 1 | 7.19 |
| CHEMBL3787630 | — | — | 1 | 7.10 |
| CHEMBL3787614 | — | — | 1 | 7.08 |
| CHEMBL3786153 | — | — | 1 | 6.70 |
| CHEMBL3786326 | — | — | 1 | 6.58 |
| CHEMBL3787112 | — | — | 1 | 6.38 |
| CHEMBL3785425 | — | — | 1 | 5.96 |
| CHEMBL3786634 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3787360 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL3786100 | — | IC50 | = | 8.3 | nM | 8.08 |
| CHEMBL3787636 | — | IC50 | = | 9.4 | nM | 8.03 |
| CHEMBL3785376 | — | IC50 | = | 9.6 | nM | 8.02 |
| CHEMBL3785995 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL3785951 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL3787271 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL1091644 | LINSITINIB | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL3786167 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL3787436 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL3787567 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL3785500 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL3786558 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL3786025 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL1614712 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL3786149 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL3787630 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL3787614 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL3786153 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL3786326 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL3787112 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL3785425 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL3786634 | — | IC50 | - | — | - |