Assay Detail
Binding
CHEMBL3789674
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of full length IGF-1 receptor (unknown origin) transfected in Ba/F3 cells assessed as cell proliferation
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | BaF3 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Insulin-like growth factor 1 receptor (CHEMBL1957) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Optimisation of a 5-[3-phenyl-(2-cyclic-ether)-methyl-ether]-4-aminopyrrolopyrimidine series of IGF-1R inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 7.61 | 8.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3786100 | — | — | 1 | 8.14 |
| CHEMBL1091644 | LINSITINIB | 3.0 | 1 | 8.12 |
| CHEMBL3787271 | — | — | 1 | 8.11 |
| CHEMBL3787567 | — | — | 1 | 7.96 |
| CHEMBL3787614 | — | — | 1 | 7.92 |
| CHEMBL3785500 | — | — | 1 | 7.85 |
| CHEMBL3786167 | — | — | 1 | 7.82 |
| CHEMBL3785951 | — | — | 1 | 7.80 |
| CHEMBL3787636 | — | — | 1 | 7.80 |
| CHEMBL1614712 | — | — | 1 | 7.70 |
| CHEMBL3786634 | — | — | 1 | 7.68 |
| CHEMBL3787436 | — | — | 1 | 7.57 |
| CHEMBL3786558 | — | — | 1 | 7.54 |
| CHEMBL3786149 | — | — | 1 | 7.33 |
| CHEMBL3787630 | — | — | 1 | 7.04 |
| CHEMBL3786153 | — | — | 1 | 6.60 |
| CHEMBL3787112 | — | — | 1 | 6.34 |
| CHEMBL3785995 | — | — | 1 | - |
| CHEMBL3785425 | — | — | 1 | - |
| CHEMBL3786326 | — | — | 1 | - |
| CHEMBL3786025 | — | — | 1 | - |
| CHEMBL3785376 | — | — | 1 | - |
| CHEMBL3787360 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3786100 | — | IC50 | = | 7.3 | nM | 8.14 |
| CHEMBL1091644 | LINSITINIB | IC50 | = | 7.6 | nM | 8.12 |
| CHEMBL3787271 | — | IC50 | = | 7.8 | nM | 8.11 |
| CHEMBL3787567 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL3787614 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL3785500 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL3786167 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL3785951 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL3787636 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL1614712 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3786634 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL3787436 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL3786558 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL3786149 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL3787630 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL3786153 | — | IC50 | = | 251.0 | nM | 6.60 |
| CHEMBL3787112 | — | IC50 | = | 454.0 | nM | 6.34 |
| CHEMBL3785995 | — | IC50 | - | — | - | |
| CHEMBL3785425 | — | IC50 | - | — | - | |
| CHEMBL3786326 | — | IC50 | - | — | - | |
| CHEMBL3786025 | — | IC50 | - | — | - | |
| CHEMBL3785376 | — | IC50 | < | 4.6 | nM | - |
| CHEMBL3787360 | — | IC50 | - | — | - |