Assay Detail
Binding
CHEMBL3789754
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Inhibition of recombinant human carbonic anhydrase 1 preincubated for 15 mins by stopped-flow CO2 hydration assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Comparison of the sulfonamide inhibition profiles of the α-, β- and γ-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 24 | 5.45 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL224292 | — | — | 1 | 8.22 |
| CHEMBL2324864 | — | — | 1 | 7.26 |
| CHEMBL6633 | — | — | 1 | 7.02 |
| CHEMBL414 | CARZENIDE | 2.0 | 1 | 6.96 |
| CHEMBL6919 | — | — | 1 | 6.79 |
| CHEMBL6784 | — | — | 1 | 6.73 |
| CHEMBL268439 | — | — | 1 | 6.16 |
| CHEMBL418 | 2,4-DISULFAMYLTRIFLUOROMETHYLANILINE | — | 1 | 5.24 |
| CHEMBL2324869 | — | — | 1 | 5.22 |
| CHEMBL6724 | — | — | 1 | 5.19 |
| CHEMBL266240 | — | — | 1 | 5.08 |
| CHEMBL6853 | — | — | 1 | 5.08 |
| CHEMBL265674 | — | — | 1 | 5.07 |
| CHEMBL6753 | — | — | 1 | 5.03 |
| CHEMBL7092 | — | — | 1 | 5.01 |
| CHEMBL7087 | — | — | 1 | 4.68 |
| CHEMBL269122 | — | — | 1 | 4.68 |
| CHEMBL266026 | — | — | 1 | 4.64 |
| CHEMBL7146 | — | — | 1 | 4.62 |
| CHEMBL419 | MAFENIDE | 4.0 | 1 | 4.60 |
| CHEMBL21 | SULFANILAMIDE | 4.0 | 1 | 4.60 |
| CHEMBL2324868 | — | — | 1 | 4.55 |
| CHEMBL6852 | — | — | 1 | 4.34 |
| CHEMBL574 | P-TOLUENESULFONAMIDE | 3.0 | 1 | 4.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL224292 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL2324864 | — | Ki | = | 55.0 | nM | 7.26 |
| CHEMBL6633 | — | Ki | = | 95.0 | nM | 7.02 |
| CHEMBL414 | CARZENIDE | Ki | = | 109.0 | nM | 6.96 |
| CHEMBL6919 | — | Ki | = | 164.0 | nM | 6.79 |
| CHEMBL6784 | — | Ki | = | 185.0 | nM | 6.73 |
| CHEMBL268439 | — | Ki | = | 690.0 | nM | 6.16 |
| CHEMBL418 | 2,4-DISULFAMYLTRIFLUOROMETHYLANILINE | Ki | = | 5800.0 | nM | 5.24 |
| CHEMBL2324869 | — | Ki | = | 6000.0 | nM | 5.22 |
| CHEMBL6724 | — | Ki | = | 6500.0 | nM | 5.19 |
| CHEMBL266240 | — | Ki | = | 8400.0 | nM | 5.08 |
| CHEMBL6853 | — | Ki | = | 8300.0 | nM | 5.08 |
| CHEMBL265674 | — | Ki | = | 8600.0 | nM | 5.07 |
| CHEMBL6753 | — | Ki | = | 9300.0 | nM | 5.03 |
| CHEMBL7092 | — | Ki | = | 9800.0 | nM | 5.01 |
| CHEMBL7087 | — | Ki | = | 21000.0 | nM | 4.68 |
| CHEMBL269122 | — | Ki | = | 21000.0 | nM | 4.68 |
| CHEMBL266026 | — | Ki | = | 23000.0 | nM | 4.64 |
| CHEMBL7146 | — | Ki | = | 24000.0 | nM | 4.62 |
| CHEMBL419 | MAFENIDE | Ki | = | 25000.0 | nM | 4.60 |
| CHEMBL21 | SULFANILAMIDE | Ki | = | 25000.0 | nM | 4.60 |
| CHEMBL2324868 | — | Ki | = | 28000.0 | nM | 4.55 |
| CHEMBL6852 | — | Ki | = | 45400.0 | nM | 4.34 |
| CHEMBL574 | P-TOLUENESULFONAMIDE | Ki | = | 78500.0 | nM | 4.11 |