Assay Detail
ADMET
CHEMBL3790093
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Cytotoxicity against HDF cells after 72 hrs by SRB assay
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | HDF |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and anticancer activity of some 5-fluoro-2'-deoxyuridine phosphoramidates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 4.68 | 5.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3785172 | — | — | 1 | 5.38 |
| CHEMBL803 | CYTARABINE | 4.0 | 1 | 5.30 |
| CHEMBL3785362 | — | — | 1 | 5.22 |
| CHEMBL3786607 | — | — | 1 | 5.21 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 5.15 |
| CHEMBL3786773 | — | — | 1 | 5.14 |
| CHEMBL3787087 | — | — | 1 | 4.93 |
| CHEMBL3786992 | — | — | 1 | 4.91 |
| CHEMBL917 | FLOXURIDINE | 4.0 | 1 | 4.88 |
| CHEMBL3787373 | — | — | 1 | 4.79 |
| CHEMBL3786921 | — | — | 1 | 4.76 |
| CHEMBL3785842 | — | — | 1 | 4.73 |
| CHEMBL3785900 | — | — | 1 | 4.57 |
| CHEMBL3787574 | — | — | 1 | 4.51 |
| CHEMBL3785877 | — | — | 1 | 4.43 |
| CHEMBL3786401 | — | — | 1 | 4.39 |
| CHEMBL2046836 | — | — | 1 | 4.37 |
| CHEMBL3786566 | — | — | 1 | 4.32 |
| CHEMBL3786198 | — | — | 1 | 4.24 |
| CHEMBL3786991 | — | — | 1 | 4.21 |
| CHEMBL3786029 | — | — | 1 | 4.21 |
| CHEMBL3785908 | — | — | 1 | 4.06 |
| CHEMBL3786421 | — | — | 1 | 4.04 |
| CHEMBL3786625 | — | — | 1 | - |
| CHEMBL3785468 | — | — | 1 | - |
| CHEMBL57053 | PARACHLOROPHENOL | -1.0 | 1 | - |
| CHEMBL3786911 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3785172 | — | IC50 | = | 4190.0 | nM | 5.38 |
| CHEMBL803 | CYTARABINE | IC50 | = | 4990.0 | nM | 5.30 |
| CHEMBL3785362 | — | IC50 | = | 6020.0 | nM | 5.22 |
| CHEMBL3786607 | — | IC50 | = | 6210.0 | nM | 5.21 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 7020.0 | nM | 5.15 |
| CHEMBL3786773 | — | IC50 | = | 7210.0 | nM | 5.14 |
| CHEMBL3787087 | — | IC50 | = | 11830.0 | nM | 4.93 |
| CHEMBL3786992 | — | IC50 | = | 12370.0 | nM | 4.91 |
| CHEMBL917 | FLOXURIDINE | IC50 | = | 13050.0 | nM | 4.88 |
| CHEMBL3787373 | — | IC50 | = | 16330.0 | nM | 4.79 |
| CHEMBL3786921 | — | IC50 | = | 17520.0 | nM | 4.76 |
| CHEMBL3785842 | — | IC50 | = | 18440.0 | nM | 4.73 |
| CHEMBL3785900 | — | IC50 | = | 27190.0 | nM | 4.57 |
| CHEMBL3787574 | — | IC50 | = | 31020.0 | nM | 4.51 |
| CHEMBL3785877 | — | IC50 | = | 37110.0 | nM | 4.43 |
| CHEMBL3786401 | — | IC50 | = | 41030.0 | nM | 4.39 |
| CHEMBL2046836 | — | IC50 | = | 43070.0 | nM | 4.37 |
| CHEMBL3786566 | — | IC50 | = | 48280.0 | nM | 4.32 |
| CHEMBL3786198 | — | IC50 | = | 57220.0 | nM | 4.24 |
| CHEMBL3786991 | — | IC50 | = | 61020.0 | nM | 4.21 |
| CHEMBL3786029 | — | IC50 | = | 61080.0 | nM | 4.21 |
| CHEMBL3785908 | — | IC50 | = | 86990.0 | nM | 4.06 |
| CHEMBL3786421 | — | IC50 | = | 92140.0 | nM | 4.04 |
| CHEMBL3786625 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3785468 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL57053 | PARACHLOROPHENOL | IC50 | = | 1850000.0 | nM | - |
| CHEMBL3786911 | — | IC50 | > | 100000.0 | nM | - |