Assay Detail
Functional
CHEMBL3792252
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against wild type HIV1 NL4-3 infected in human MT2 cells after 4 to 5 days by dual-luciferase reporter gene assay in presence of human serum albumin
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Inhibitors of HIV-1 maturation: Development of structure-activity relationship for C-28 amides based on C-3 benzoic acid-modified triterpenoids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 15 | 7.11 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3787611 | — | — | 1 | 8.52 |
| CHEMBL3785869 | — | — | 1 | 8.05 |
| CHEMBL3787468 | — | — | 1 | 7.96 |
| CHEMBL3785793 | — | — | 1 | 7.77 |
| CHEMBL3786393 | — | — | 1 | 7.66 |
| CHEMBL3787481 | — | — | 1 | 7.55 |
| CHEMBL3785147 | — | — | 1 | 7.55 |
| CHEMBL3787154 | — | — | 1 | 7.41 |
| CHEMBL3775172 | — | — | 1 | 6.82 |
| CHEMBL3785394 | — | — | 1 | 6.78 |
| CHEMBL3785897 | — | — | 1 | 6.59 |
| CHEMBL3786166 | — | — | 1 | 6.35 |
| CHEMBL404519 | BEVIRIMAT | 2.0 | 1 | 6.01 |
| CHEMBL3786219 | — | — | 1 | 5.82 |
| CHEMBL3786856 | — | — | 1 | 5.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3787611 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3785869 | — | EC50 | = | 9.0 | nM | 8.05 |
| CHEMBL3787468 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL3785793 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL3786393 | — | EC50 | = | 22.0 | nM | 7.66 |
| CHEMBL3787481 | — | EC50 | = | 28.0 | nM | 7.55 |
| CHEMBL3785147 | — | EC50 | = | 28.0 | nM | 7.55 |
| CHEMBL3787154 | — | EC50 | = | 39.0 | nM | 7.41 |
| CHEMBL3775172 | — | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL3785394 | — | EC50 | = | 166.0 | nM | 6.78 |
| CHEMBL3785897 | — | EC50 | = | 255.0 | nM | 6.59 |
| CHEMBL3786166 | — | EC50 | = | 449.0 | nM | 6.35 |
| CHEMBL404519 | BEVIRIMAT | EC50 | = | 974.0 | nM | 6.01 |
| CHEMBL3786219 | — | EC50 | = | 1516.0 | nM | 5.82 |
| CHEMBL3786856 | — | EC50 | = | 1583.0 | nM | 5.80 |