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Assay Detail

CHEMBL3792254

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against wild type HIV1 NL4-3 habouring Gag protein delta V370 infected in human MT2 cells after 4 to 5 days by dual-luciferase reporter gene assay
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Human immunodeficiency virus 1
Cell Type MT2
Confidence 1 — Organism
Curated By Autocuration

Target

Human immunodeficiency virus 1 (CHEMBL378)
Type ORGANISM
Organism Human immunodeficiency virus 1

Publication

Inhibitors of HIV-1 maturation: Development of structure-activity relationship for C-28 amides based on C-3 benzoic acid-modified triterpenoids.
Swidorski JJ, Liu Z, Sit SY, Chen J, Chen Y, Sin N, Venables BL, Parker DD, Nowicka-Sans B, Terry BJ, Protack T, Rahematpura S, Hanumegowda U, Jenkins S, Krystal M, Dicker IB, Meanwell NA, Regueiro-Ren A.
Bioorg Med Chem Lett (2016) 26 : 1925 -1930
PubMed 26988305 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 28 6.67 7.60

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3785793 1 7.60
CHEMBL3787468 1 7.51
CHEMBL3785772 1 7.41
CHEMBL3787611 1 7.30
CHEMBL3785640 1 7.21
CHEMBL3785258 1 7.19
CHEMBL3787677 1 7.16
CHEMBL3787481 1 7.11
CHEMBL3785743 1 6.92
CHEMBL3787076 1 6.80
CHEMBL3785837 1 6.65
CHEMBL3786885 1 6.45
CHEMBL3786393 1 6.44
CHEMBL3785348 1 6.38
CHEMBL3785897 1 6.17
CHEMBL3785642 1 6.16
CHEMBL3785203 1 6.15
CHEMBL3787318 1 6.10
CHEMBL3785394 1 5.93
CHEMBL3785458 1 5.79
CHEMBL3787207 1 5.70
CHEMBL3787154 1 -
CHEMBL3786166 1 -
CHEMBL3785346 1 -
CHEMBL3785518 1 -
CHEMBL404519 BEVIRIMAT 2.0 1 -
CHEMBL3787595 1 -
CHEMBL3775172 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3785793 EC50 = 25.0 nM 7.60
CHEMBL3787468 EC50 = 31.0 nM 7.51
CHEMBL3785772 EC50 = 39.0 nM 7.41
CHEMBL3787611 EC50 = 50.0 nM 7.30
CHEMBL3785640 EC50 = 61.0 nM 7.21
CHEMBL3785258 EC50 = 64.0 nM 7.19
CHEMBL3787677 EC50 = 69.0 nM 7.16
CHEMBL3787481 EC50 = 77.0 nM 7.11
CHEMBL3785743 EC50 = 119.0 nM 6.92
CHEMBL3787076 EC50 = 160.0 nM 6.80
CHEMBL3785837 EC50 = 224.0 nM 6.65
CHEMBL3786885 EC50 = 359.0 nM 6.45
CHEMBL3786393 EC50 = 361.0 nM 6.44
CHEMBL3785348 EC50 = 415.0 nM 6.38
CHEMBL3785897 EC50 = 676.0 nM 6.17
CHEMBL3785642 EC50 = 690.0 nM 6.16
CHEMBL3785203 EC50 = 702.0 nM 6.15
CHEMBL3787318 EC50 = 800.0 nM 6.10
CHEMBL3785394 EC50 = 1186.0 nM 5.93
CHEMBL3785458 EC50 = 1613.0 nM 5.79
CHEMBL3787207 EC50 = 2000.0 nM 5.70
CHEMBL3787154 EC50 > 2000.0 nM -
CHEMBL3786166 EC50 > 4000.0 nM -
CHEMBL3785346 EC50 > 2000.0 nM -
CHEMBL3785518 EC50 > 160.0 nM -
CHEMBL404519 BEVIRIMAT EC50 > 10000.0 nM -
CHEMBL3787595 EC50 > 2000.0 nM -
CHEMBL3775172 EC50 > 6000.0 nM -