Assay Detail
Binding
CHEMBL3795202
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to FKBP51 (unknown origin) by competitive fluorescence polarization assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Peptidyl-prolyl cis-trans isomerase FKBP5 (CHEMBL2052031) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Rapid, Structure-Based Exploration of Pipecolic Acid Amides as Novel Selective Antagonists of the FK506-Binding Protein 51.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 7.91 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3623612 | — | — | 1 | 8.40 |
| CHEMBL3623630 | — | — | 1 | 8.22 |
| CHEMBL269732 | TACROLIMUS ANHYDROUS | 4.0 | 1 | 7.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3623612 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL3623630 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL269732 | TACROLIMUS ANHYDROUS | Ki | = | 79.0 | nM | 7.10 |