Assay Detail
Functional
CHEMBL3795417
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Cytotoxicity against human Bcl-XL dependant MOLT4 cells by cell based assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MOLT-4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Selective inhibitors of Bcl-2 and Bcl-xL: Balancing antitumor activity with on-target toxicity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 7.69 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3793424 | — | — | 1 | 8.22 |
| CHEMBL3342332 | A-1155463 | — | 1 | 7.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3793424 | — | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL3342332 | A-1155463 | EC50 | = | 70.0 | nM | 7.16 |