Assay Detail
Binding
CHEMBL3796125
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HDAC4 in human Jurkat E6-1 cells using Lys-TFA as substrate
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Jurkat |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Potent, Selective, and CNS-Penetrant Tetrasubstituted Cyclopropane Class IIa Histone Deacetylase (HDAC) Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 6.50 | 6.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3793439 | — | — | 1 | 6.92 |
| CHEMBL3793392 | — | — | 1 | 6.92 |
| CHEMBL3792545 | — | — | 1 | 6.89 |
| CHEMBL3794485 | — | — | 1 | 6.82 |
| CHEMBL3110021 | — | — | 1 | 6.64 |
| CHEMBL3794140 | — | — | 1 | 6.64 |
| CHEMBL3793932 | — | — | 1 | 6.55 |
| CHEMBL3110015 | — | — | 1 | 6.48 |
| CHEMBL3794544 | — | — | 1 | 6.37 |
| CHEMBL3793034 | — | — | 1 | 6.29 |
| CHEMBL3793739 | — | — | 1 | 6.26 |
| CHEMBL3794334 | — | — | 1 | 6.17 |
| CHEMBL3793569 | — | — | 1 | 6.14 |
| CHEMBL3793455 | — | — | 1 | 5.94 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3793439 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL3793392 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL3792545 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL3794485 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL3110021 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL3794140 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL3793932 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL3110015 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL3794544 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL3793034 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL3793739 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL3794334 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL3793569 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL3793455 | — | IC50 | = | 1150.0 | nM | 5.94 |