Assay Detail
Binding
CHEMBL3796330
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Inhibition of Influenza A virus PR/8/34 6His-tagged PA (239 to 716 residues) interaction with GST-tagged PB1 (1 to 25 residues) expressed in Escherichia coli compound treated in PBS buffer measured after overnight incubation by ELISA
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Influenza A virus (A/Puerto Rico/8/1934(H1N1)) |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
PA/PB1 (CHEMBL3137263) ↗| Type | PROTEIN-PROTEIN INTERACTION |
| Organism | Influenza A virus (A/Puerto Rico/8/1934(H1N1)) |
Publication
4,6-Diphenylpyridines as Promising Novel Anti-Influenza Agents Targeting the PA-PB1 Protein-Protein Interaction: Structure-Activity Relationships Exploration with the Aid of Molecular Modeling.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 4.37 | 4.45 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3110332 | — | — | 1 | 4.45 |
| CHEMBL3794203 | — | — | 1 | 4.28 |
| CHEMBL1229 | OSELTAMIVIR | 4.0 | 1 | - |
| CHEMBL1643 | RIBAVIRIN | 4.0 | 1 | - |
| CHEMBL3792827 | — | — | 1 | - |
| CHEMBL3794263 | — | — | 1 | - |
| CHEMBL3792526 | — | — | 1 | - |
| CHEMBL3792635 | — | — | 1 | - |
| CHEMBL3793877 | — | — | 1 | - |
| CHEMBL3792991 | — | — | 1 | - |
| CHEMBL3794124 | — | — | 1 | - |
| CHEMBL3794520 | — | — | 1 | - |
| CHEMBL3794048 | — | — | 1 | - |
| CHEMBL3794429 | — | — | 1 | - |
| CHEMBL3793619 | — | — | 1 | - |
| CHEMBL3794234 | — | — | 1 | - |
| CHEMBL3792444 | — | — | 1 | - |
| CHEMBL3793346 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3110332 | — | IC50 | = | 35900.0 | nM | 4.45 |
| CHEMBL3794203 | — | IC50 | = | 52600.0 | nM | 4.28 |
| CHEMBL1229 | OSELTAMIVIR | IC50 | - | — | - | |
| CHEMBL1643 | RIBAVIRIN | IC50 | - | — | - | |
| CHEMBL3792827 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL3794263 | — | IC50 | = | 165000.0 | nM | - |
| CHEMBL3792526 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL3792635 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL3793877 | — | IC50 | = | 116000.0 | nM | - |
| CHEMBL3792991 | — | IC50 | = | 140000.0 | nM | - |
| CHEMBL3794124 | — | IC50 | = | 122000.0 | nM | - |
| CHEMBL3794520 | — | IC50 | = | 190000.0 | nM | - |
| CHEMBL3794048 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL3794429 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL3793619 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL3794234 | — | IC50 | = | 177000.0 | nM | - |
| CHEMBL3792444 | — | IC50 | = | 175000.0 | nM | - |
| CHEMBL3793346 | — | IC50 | = | 195000.0 | nM | - |