Assay Detail
Binding
CHEMBL3796505
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Binding affinity to HDAC4 catalytic domain (unknown origin) by surface plasmon resonance assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Potent, Selective, and CNS-Penetrant Tetrasubstituted Cyclopropane Class IIa Histone Deacetylase (HDAC) Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 3 | 7.25 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3793392 | — | — | 1 | 7.70 |
| CHEMBL3794485 | — | — | 1 | 7.10 |
| CHEMBL3110015 | — | — | 1 | 6.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3793392 | — | Kd | = | 20.0 | nM | 7.70 |
| CHEMBL3794485 | — | Kd | = | 80.0 | nM | 7.10 |
| CHEMBL3110015 | — | Kd | = | 110.0 | nM | 6.96 |