Assay Detail
Binding
CHEMBL3796508
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Inhibition of HDAC4 catalytic domain (unknown origin) using Boc-Lys(TFA)-AMC as substrate
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Potent, Selective, and CNS-Penetrant Tetrasubstituted Cyclopropane Class IIa Histone Deacetylase (HDAC) Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 7.33 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3793392 | — | — | 1 | 8.00 |
| CHEMBL3793439 | — | — | 1 | 8.00 |
| CHEMBL3792545 | — | — | 1 | 7.70 |
| CHEMBL3794485 | — | — | 1 | 7.52 |
| CHEMBL3110021 | — | — | 1 | 7.52 |
| CHEMBL3794140 | — | — | 1 | 7.40 |
| CHEMBL3793932 | — | — | 1 | 7.40 |
| CHEMBL3793569 | — | — | 1 | 7.30 |
| CHEMBL3110015 | — | — | 1 | 7.30 |
| CHEMBL3794334 | — | — | 1 | 7.10 |
| CHEMBL3793455 | — | — | 1 | 6.96 |
| CHEMBL3794544 | — | — | 1 | 6.85 |
| CHEMBL3793739 | — | — | 1 | 6.82 |
| CHEMBL3793034 | — | — | 1 | 6.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3793392 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3793439 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3792545 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3794485 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL3110021 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL3794140 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL3793932 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL3793569 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3110015 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3794334 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL3793455 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL3794544 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL3793739 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL3793034 | — | IC50 | = | 180.0 | nM | 6.75 |