Assay Detail
Functional
CHEMBL3796706
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Vasorelaxant activity in Wistar rat endothelium-intact thoracic aortic rings assessed relaxation of 30 mM KCl-induced contraction
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Thoracic aorta |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis, characterization and biological evaluation of benzothiazoles and tetrahydrobenzothiazoles bearing urea or thiourea moieties as vasorelaxants and inhibitors of the insulin releasing process.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 32 | 4.78 | 6.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1159 | PINACIDIL ANHYDROUS | 4.0 | 1 | 6.41 |
| CHEMBL3793351 | — | — | 1 | 5.68 |
| CHEMBL3794338 | — | — | 1 | 5.56 |
| CHEMBL3793214 | — | — | 1 | 4.97 |
| CHEMBL3792527 | — | — | 1 | 4.88 |
| CHEMBL3794138 | — | — | 1 | 4.83 |
| CHEMBL3793115 | — | — | 1 | 4.80 |
| CHEMBL3792605 | — | — | 1 | 4.73 |
| CHEMBL3793842 | — | — | 1 | 4.64 |
| CHEMBL181 | DIAZOXIDE | 4.0 | 1 | 4.63 |
| CHEMBL3793765 | — | — | 1 | 4.61 |
| CHEMBL3794361 | — | — | 1 | 4.60 |
| CHEMBL3794458 | — | — | 1 | 4.45 |
| CHEMBL3793813 | — | — | 1 | 4.32 |
| CHEMBL3793803 | — | — | 1 | 4.28 |
| CHEMBL3793821 | — | — | 1 | 4.26 |
| CHEMBL3792829 | — | — | 1 | 4.19 |
| CHEMBL3792629 | — | — | 1 | 4.12 |
| CHEMBL3794499 | — | — | 1 | - |
| CHEMBL3793328 | — | — | 1 | - |
| CHEMBL3794432 | — | — | 1 | - |
| CHEMBL3793950 | — | — | 1 | - |
| CHEMBL3794118 | — | — | 1 | - |
| CHEMBL3792631 | — | — | 1 | - |
| CHEMBL3794022 | — | — | 1 | - |
| CHEMBL3793493 | — | — | 1 | - |
| CHEMBL3793626 | — | — | 1 | - |
| CHEMBL3792822 | — | — | 1 | - |
| CHEMBL3794339 | — | — | 1 | - |
| CHEMBL3793495 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1159 | PINACIDIL ANHYDROUS | EC50 | = | 390.0 | nM | 6.41 |
| CHEMBL3793351 | — | EC50 | = | 2110.0 | nM | 5.68 |
| CHEMBL3794338 | — | EC50 | = | 2780.0 | nM | 5.56 |
| CHEMBL3793214 | — | EC50 | = | 10760.0 | nM | 4.97 |
| CHEMBL3792527 | — | EC50 | = | 13030.0 | nM | 4.88 |
| CHEMBL3794138 | — | EC50 | = | 14760.0 | nM | 4.83 |
| CHEMBL3793115 | — | EC50 | = | 15700.0 | nM | 4.80 |
| CHEMBL3792605 | — | EC50 | = | 18470.0 | nM | 4.73 |
| CHEMBL3793842 | — | EC50 | = | 22790.0 | nM | 4.64 |
| CHEMBL181 | DIAZOXIDE | EC50 | = | 23680.0 | nM | 4.63 |
| CHEMBL3793765 | — | EC50 | = | 24400.0 | nM | 4.61 |
| CHEMBL3794361 | — | EC50 | = | 25270.0 | nM | 4.60 |
| CHEMBL3794458 | — | EC50 | = | 35490.0 | nM | 4.45 |
| CHEMBL3793813 | — | EC50 | = | 47630.0 | nM | 4.32 |
| CHEMBL3793803 | — | EC50 | = | 52060.0 | nM | 4.28 |
| CHEMBL3793821 | — | EC50 | = | 54320.0 | nM | 4.26 |
| CHEMBL3792829 | — | EC50 | = | 64200.0 | nM | 4.19 |
| CHEMBL3792629 | — | EC50 | = | 75240.0 | nM | 4.12 |
| CHEMBL3794499 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL3793328 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL3794432 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL3793950 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL3794118 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL3792631 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL3794022 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL3793493 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL3793626 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL3792822 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL3794339 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL3793495 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL3792399 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL3792418 | — | EC50 | > | 100000.0 | nM | - |