Assay Detail
Functional
CHEMBL3796709
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Vasorelaxant activity in Wistar rat thoracic aortic rings assessed relaxation of 80 mM KCl-induced contraction
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Thoracic aorta |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis, characterization and biological evaluation of benzothiazoles and tetrahydrobenzothiazoles bearing urea or thiourea moieties as vasorelaxants and inhibitors of the insulin releasing process.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 4.54 | 4.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3793351 | — | — | 1 | 4.85 |
| CHEMBL3794338 | — | — | 1 | 4.82 |
| CHEMBL3792527 | — | — | 1 | 4.57 |
| CHEMBL3793214 | — | — | 1 | 4.51 |
| CHEMBL3793115 | — | — | 1 | 4.44 |
| CHEMBL1159 | PINACIDIL ANHYDROUS | 4.0 | 1 | 4.04 |
| CHEMBL181 | DIAZOXIDE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3793351 | — | EC50 | = | 14190.0 | nM | 4.85 |
| CHEMBL3794338 | — | EC50 | = | 15020.0 | nM | 4.82 |
| CHEMBL3792527 | — | EC50 | = | 26870.0 | nM | 4.57 |
| CHEMBL3793214 | — | EC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL3793115 | — | EC50 | = | 36390.0 | nM | 4.44 |
| CHEMBL1159 | PINACIDIL ANHYDROUS | EC50 | = | 92060.0 | nM | 4.04 |
| CHEMBL181 | DIAZOXIDE | EC50 | > | 100000.0 | nM | - |