Assay Detail
Functional
CHEMBL3796864
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antimicrobial activity against Chlamydia trachomatis serovar LGV-L2 infected in human HeLa cells assessed as decrease in relative inclusion forming units measured 44 to 48 hrs post infection by DAPI staining-based assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Chlamydia trachomatis |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Thiazolino 2-Pyridone Amide Inhibitors of Chlamydia trachomatis Infectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 6.80 | 7.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3794197 | — | — | 1 | 7.23 |
| CHEMBL3792660 | — | — | 1 | 6.99 |
| CHEMBL3793721 | — | — | 1 | 6.85 |
| CHEMBL3793415 | — | — | 1 | 6.83 |
| CHEMBL3794069 | — | — | 1 | 6.59 |
| CHEMBL3793761 | — | — | 1 | 6.58 |
| CHEMBL3793180 | — | — | 1 | 6.55 |
| CHEMBL3793676 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3794197 | — | EC50 | = | 59.0 | nM | 7.23 |
| CHEMBL3792660 | — | EC50 | = | 102.0 | nM | 6.99 |
| CHEMBL3793721 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL3793415 | — | EC50 | = | 147.0 | nM | 6.83 |
| CHEMBL3794069 | — | EC50 | = | 254.0 | nM | 6.59 |
| CHEMBL3793761 | — | EC50 | = | 266.0 | nM | 6.58 |
| CHEMBL3793180 | — | EC50 | = | 281.0 | nM | 6.55 |
| CHEMBL3793676 | — | EC50 | - | — | - |