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Assay Detail

CHEMBL3800828

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human HT-29 cells after 96 hrs by SRB assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HT-29
Confidence 1 — Organism
Curated By Autocuration

Target

HT-29 (CHEMBL384)
Type CELL-LINE
Organism Homo sapiens

Publication

Amino(oxo)acetate moiety: A new functional group to improve the cytotoxicity of betulin derived carbamates.
Heller L, Perl V, Wiemann J, Al-Harrasi A, Csuk R.
Bioorg Med Chem Lett (2016) 26 : 2852 -2854
PubMed 27142753 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 19 4.87 5.14

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3798687 1 5.14
CHEMBL3740001 1 5.12
CHEMBL3798515 1 5.00
CHEMBL3798973 1 4.89
CHEMBL269277 BETULINIC ACID 1.0 1 4.84
CHEMBL3797796 1 4.82
CHEMBL3740094 1 4.79
CHEMBL3739882 1 4.79
CHEMBL3800639 1 4.67
CHEMBL359080 BETULIN DIACETATE 1 4.59
CHEMBL3741706 1 -
CHEMBL3739781 1 -
CHEMBL3739697 1 -
CHEMBL3739637 1 -
CHEMBL3739751 1 -
CHEMBL3741347 1 -
CHEMBL3741068 1 -
CHEMBL1087415 1 -
CHEMBL23236 BETULIN 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3798687 EC50 = 7300.0 nM 5.14
CHEMBL3740001 EC50 = 7500.0 nM 5.12
CHEMBL3798515 EC50 = 10100.0 nM 5.00
CHEMBL3798973 EC50 = 12800.0 nM 4.89
CHEMBL269277 BETULINIC ACID EC50 = 14400.0 nM 4.84
CHEMBL3797796 EC50 = 15300.0 nM 4.82
CHEMBL3740094 EC50 = 16300.0 nM 4.79
CHEMBL3739882 EC50 = 16300.0 nM 4.79
CHEMBL3800639 EC50 = 21400.0 nM 4.67
CHEMBL359080 BETULIN DIACETATE EC50 = 25700.0 nM 4.59
CHEMBL3741706 EC50 > 30000.0 nM -
CHEMBL3739781 EC50 > 30000.0 nM -
CHEMBL3739697 EC50 > 30000.0 nM -
CHEMBL3739637 EC50 > 30000.0 nM -
CHEMBL3739751 EC50 > 30000.0 nM -
CHEMBL3741347 EC50 > 30000.0 nM -
CHEMBL3741068 EC50 > 30000.0 nM -
CHEMBL1087415 EC50 > 30000.0 nM -
CHEMBL23236 BETULIN EC50 > 30000.0 nM -