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Compound Detail

CHEMBL3739781

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C=C(C)[C@@H]1CC[C@]2(COC(=O)NCCCCCC)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12

Basic Information

ChEMBL ID CHEMBL3739781
Phase Preclinical
Structure Type MOL
InChI Key BMAJLGYPUDHYIU-COUXBJNASA-N
4
Targets
8
Activities
1
Assay Types
0
PK Parameters
13
Publications
0
Known Names

Molecular Properties

569.9
MW (Da)
9.31
ALogP
3
HBA
2
HBD
58.6
PSA (Ų)
0.23
QED
2
Ro5 Violations
8
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C37H63NO3
MW 569.92
Aromatic Rings 0
Heavy Atoms 41
NP-Likeness 2.41

Activity Summary

EC50 8 meas. best 5.26

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
NON-PROTEIN TARGET
CHEMBL3879801
EC50 5.26 5.255 5500.0 2
HeLa
CHEMBL399
EC50 5.13 5.13 7400.0 2
A2780
CHEMBL614004
EC50 5.12 5.115 7600.0 2
A549
CHEMBL392
EC50 4.9 4.9 12700.0 2

Activity Data Samples

Top measurements by pChEMBL value

Literature References

Data from ChEMBL 36 via Core Engine