Assay Detail
Functional
CHEMBL3800939
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 BAL infected in human TZM-bl cells assessed as inhibition of viral infection
10
Total Activities
9
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | TZM-bl |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Synthesis and bioevaluation of substituted chalcones, coumaranones and other flavonoids as anti-HIV agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.78 | 5.36 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2386666 | — | — | 1 | 5.36 |
| CHEMBL2386680 | — | — | 2 | 5.33 |
| CHEMBL2386683 | — | — | 1 | 4.98 |
| CHEMBL2386689 | — | — | 1 | 4.90 |
| CHEMBL2386681 | — | — | 1 | 4.70 |
| CHEMBL244746 | — | — | 1 | 4.52 |
| CHEMBL2386684 | — | — | 1 | 4.51 |
| CHEMBL2386541 | — | — | 1 | 4.37 |
| CHEMBL2386682 | — | — | 1 | 4.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2386666 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL2386680 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL2386683 | — | IC50 | = | 10400.0 | nM | 4.98 |
| CHEMBL2386689 | — | IC50 | = | 12600.0 | nM | 4.90 |
| CHEMBL2386681 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL244746 | — | IC50 | = | 30400.0 | nM | 4.52 |
| CHEMBL2386684 | — | IC50 | = | 30900.0 | nM | 4.51 |
| CHEMBL2386541 | — | IC50 | = | 42300.0 | nM | 4.37 |
| CHEMBL2386682 | — | IC50 | = | 43700.0 | nM | 4.36 |
| CHEMBL2386680 | — | Inhibition | - | % | - |