Assay Detail
Binding
CHEMBL3801327
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human ABL using (poly [Glu, Tyr] 4:1) as substrate assessed as incorporation of 33P in substrate by [gamma33P] ATP-based kinase assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
eCF309: a potent, selective and cell-permeable mTOR inhibitor
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.33 | 5.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3799221 | — | — | 1 | 5.92 |
| CHEMBL3797590 | — | — | 1 | 5.06 |
| CHEMBL3800138 | — | — | 1 | 5.00 |
| CHEMBL3800481 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3799221 | — | IC50 | = | 1210.0 | nM | 5.92 |
| CHEMBL3797590 | — | IC50 | = | 8630.0 | nM | 5.06 |
| CHEMBL3800138 | — | IC50 | = | 9920.0 | nM | 5.00 |
| CHEMBL3800481 | — | IC50 | > | 100000.0 | nM | - |