Assay Detail
Functional
CHEMBL3801377
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Antiviral activity against Tick-borne encephalitis virus Absettarov infected in PEK cells assessed as reduction in viral plaque formation compounds preincubated with virus for 1 hr followed by addition of cells with subsequent incubation of 1 hr measured after 6 days by gentian violet staining
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Tick-borne encephalitis virus |
| Cell Type | PEK |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Rigid amphipathic nucleosides suppress reproduction of the tick-borne encephalitis virus
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 7.01 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3797928 | — | — | 1 | 7.40 |
| CHEMBL3798024 | — | — | 1 | 7.40 |
| CHEMBL3797341 | — | — | 1 | 6.22 |
| CHEMBL3797950 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3797928 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL3798024 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL3797341 | — | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL3797950 | — | EC50 | - | — | - |