Assay Detail
Binding
CHEMBL3801461
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting method
22
Total Activities
22
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
2,8-Diazaspiro[4.5]decan-8-yl)pyrimidin-4-amine potent CCR4 antagonists capable of inducing receptor endocytosis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 21 | 7.75 | 9.00 |
| pKi | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3797662 | — | — | 1 | 9.00 |
| CHEMBL3799266 | — | — | 1 | 8.80 |
| CHEMBL372399 | — | — | 1 | 8.60 |
| CHEMBL3797537 | — | — | 1 | 8.60 |
| CHEMBL2018954 | — | — | 1 | 8.50 |
| CHEMBL3799578 | — | — | 1 | 8.50 |
| CHEMBL3798452 | — | — | 1 | 8.40 |
| CHEMBL3799393 | — | — | 1 | 8.30 |
| CHEMBL3799025 | — | — | 1 | 7.80 |
| CHEMBL3797567 | — | — | 1 | 7.70 |
| CHEMBL3799865 | — | — | 1 | 7.60 |
| CHEMBL3799514 | — | — | 1 | 7.60 |
| CHEMBL3798263 | — | — | 1 | 7.60 |
| CHEMBL3797980 | — | — | 1 | 7.60 |
| CHEMBL3798941 | — | — | 1 | 7.30 |
| CHEMBL3798949 | — | — | 1 | 7.30 |
| CHEMBL3798539 | — | — | 1 | 7.00 |
| CHEMBL3799904 | — | — | 1 | 7.00 |
| CHEMBL3797946 | — | — | 1 | 6.90 |
| CHEMBL3797678 | — | — | 1 | 6.50 |
| CHEMBL3797555 | — | — | 1 | 6.20 |
| CHEMBL3799959 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3797662 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL3799266 | — | Ki | = | 1.585 | nM | 8.80 |
| CHEMBL372399 | — | Ki | = | 2.512 | nM | 8.60 |
| CHEMBL3797537 | — | Ki | = | 2.512 | nM | 8.60 |
| CHEMBL2018954 | — | Ki | = | 3.162 | nM | 8.50 |
| CHEMBL3799578 | — | Ki | = | 3.162 | nM | 8.50 |
| CHEMBL3798452 | — | Ki | = | 3.981 | nM | 8.40 |
| CHEMBL3799393 | — | Ki | = | 5.012 | nM | 8.30 |
| CHEMBL3799025 | — | Ki | = | 15.85 | nM | 7.80 |
| CHEMBL3797567 | — | Ki | = | 19.95 | nM | 7.70 |
| CHEMBL3799865 | — | Ki | = | 25.12 | nM | 7.60 |
| CHEMBL3799514 | — | Ki | = | 25.12 | nM | 7.60 |
| CHEMBL3798263 | — | Ki | = | 25.12 | nM | 7.60 |
| CHEMBL3797980 | — | Ki | = | 25.12 | nM | 7.60 |
| CHEMBL3798941 | — | Ki | = | 50.12 | nM | 7.30 |
| CHEMBL3798949 | — | Ki | = | 50.12 | nM | 7.30 |
| CHEMBL3798539 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL3799904 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL3797946 | — | Ki | = | 125.89 | nM | 6.90 |
| CHEMBL3797678 | — | Ki | = | 316.23 | nM | 6.50 |
| CHEMBL3797555 | — | Ki | = | 630.96 | nM | 6.20 |
| CHEMBL3799959 | — | pKi | - | — | - |