Assay Detail
Binding
CHEMBL3801463
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at CCR4 in human PBMC assessed as inhibition of actin polymerization by flow cytometry
23
Total Activities
23
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
2,8-Diazaspiro[4.5]decan-8-yl)pyrimidin-4-amine potent CCR4 antagonists capable of inducing receptor endocytosis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| pA2 | 18 | - | - |
| Kd | 5 | 6.45 | 6.76 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL372399 | — | — | 1 | 6.76 |
| CHEMBL3799266 | — | — | 1 | 6.70 |
| CHEMBL2018954 | — | — | 1 | 6.60 |
| CHEMBL2018969 | — | — | 1 | 6.20 |
| CHEMBL3797662 | — | — | 1 | 6.00 |
| CHEMBL3799904 | — | — | 1 | - |
| CHEMBL3797980 | — | — | 1 | - |
| CHEMBL3797567 | — | — | 1 | - |
| CHEMBL3798941 | — | — | 1 | - |
| CHEMBL3798949 | — | — | 1 | - |
| CHEMBL3797946 | — | — | 1 | - |
| CHEMBL3797555 | — | — | 1 | - |
| CHEMBL3798539 | — | — | 1 | - |
| CHEMBL3799025 | — | — | 1 | - |
| CHEMBL3798263 | — | — | 1 | - |
| CHEMBL3798452 | — | — | 1 | - |
| CHEMBL3799393 | — | — | 1 | - |
| CHEMBL3797537 | — | — | 1 | - |
| CHEMBL3799865 | — | — | 1 | - |
| CHEMBL3799578 | — | — | 1 | - |
| CHEMBL3799514 | — | — | 1 | - |
| CHEMBL3797678 | — | — | 1 | - |
| CHEMBL3799959 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL372399 | — | Kd | = | 173.78 | nM | 6.76 |
| CHEMBL3799266 | — | Kd | = | 199.53 | nM | 6.70 |
| CHEMBL2018954 | — | Kd | = | 251.19 | nM | 6.60 |
| CHEMBL2018969 | — | Kd | = | 630.96 | nM | 6.20 |
| CHEMBL3797662 | — | Kd | = | 1000.0 | nM | 6.00 |
| CHEMBL3799904 | — | pA2 | - | — | - | |
| CHEMBL3797980 | — | pA2 | - | — | - | |
| CHEMBL3797567 | — | pA2 | - | — | - | |
| CHEMBL3798941 | — | pA2 | - | — | - | |
| CHEMBL3798949 | — | pA2 | - | — | - | |
| CHEMBL3797946 | — | pA2 | - | — | - | |
| CHEMBL3797555 | — | pA2 | - | — | - | |
| CHEMBL3798539 | — | pA2 | - | — | - | |
| CHEMBL3799025 | — | pA2 | - | — | - | |
| CHEMBL3798263 | — | pA2 | - | — | - | |
| CHEMBL3798452 | — | pA2 | - | — | - | |
| CHEMBL3799393 | — | pA2 | - | — | - | |
| CHEMBL3797537 | — | pA2 | - | — | - | |
| CHEMBL3799865 | — | pA2 | - | — | - | |
| CHEMBL3799578 | — | pA2 | - | — | - | |
| CHEMBL3799514 | — | pA2 | - | — | - | |
| CHEMBL3797678 | — | pA2 | - | — | - | |
| CHEMBL3799959 | — | pA2 | - | — | - |