Assay Detail
Binding
CHEMBL3801488
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Agonist activity at PK-tagged beta2 receptor (unknown origin) transfected in HEK293 cells after 90 mins by beta-arrestin assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-guided development of dual β2 adrenergic/dopamine D2 receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 6.68 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3798748 | — | — | 1 | 7.89 |
| CHEMBL3800400 | — | — | 1 | 7.66 |
| CHEMBL434 | ISOPROTERENOL | 4.0 | 1 | 6.92 |
| CHEMBL3797876 | — | — | 1 | 6.68 |
| CHEMBL3800303 | — | — | 1 | 6.58 |
| CHEMBL3800468 | — | — | 1 | 6.29 |
| CHEMBL3797205 | — | — | 1 | 6.24 |
| CHEMBL3799427 | — | — | 1 | 6.19 |
| CHEMBL3799593 | — | — | 1 | 5.66 |
| CHEMBL240773 | QUINPIROLE | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3798748 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3800400 | — | EC50 | = | 22.0 | nM | 7.66 |
| CHEMBL434 | ISOPROTERENOL | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL3797876 | — | EC50 | = | 210.0 | nM | 6.68 |
| CHEMBL3800303 | — | EC50 | = | 260.0 | nM | 6.58 |
| CHEMBL3800468 | — | EC50 | = | 510.0 | nM | 6.29 |
| CHEMBL3797205 | — | EC50 | = | 580.0 | nM | 6.24 |
| CHEMBL3799427 | — | EC50 | = | 650.0 | nM | 6.19 |
| CHEMBL3799593 | — | EC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL240773 | QUINPIROLE | EC50 | - | — | - |