Assay Detail
Functional
CHEMBL3801747
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Agonist activity at human S1P3 receptor expressed in EDG3-Ga15-bla HEK293T cell membranes after 45 mins by [35S]-GTPgammaS binding assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK-293T |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Potent and Selective Agonists of Sphingosine 1-Phosphate 1 (S1P1): Discovery and SAR of a Novel Isoxazole Based Series.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 18 | 5.69 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3798784 | — | — | 1 | 6.89 |
| CHEMBL3799701 | — | — | 1 | 6.17 |
| CHEMBL3797415 | — | — | 1 | 6.14 |
| CHEMBL3797951 | — | — | 1 | 6.07 |
| CHEMBL3800257 | — | — | 1 | 6.00 |
| CHEMBL3799693 | — | — | 1 | 5.89 |
| CHEMBL3794064 | — | — | 1 | 5.80 |
| CHEMBL3798775 | — | — | 1 | 5.75 |
| CHEMBL3798735 | — | — | 1 | 5.72 |
| CHEMBL3798531 | — | — | 1 | 5.58 |
| CHEMBL3800349 | — | — | 1 | 5.39 |
| CHEMBL3800513 | — | — | 1 | 5.29 |
| CHEMBL3800091 | — | — | 1 | 5.21 |
| CHEMBL3799501 | — | — | 1 | 5.20 |
| CHEMBL3799276 | — | — | 1 | 5.04 |
| CHEMBL3800595 | — | — | 1 | 4.92 |
| CHEMBL3798560 | — | — | 1 | - |
| CHEMBL3800122 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3798784 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL3799701 | — | EC50 | = | 680.0 | nM | 6.17 |
| CHEMBL3797415 | — | EC50 | = | 730.0 | nM | 6.14 |
| CHEMBL3797951 | — | EC50 | = | 850.0 | nM | 6.07 |
| CHEMBL3800257 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3799693 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL3794064 | — | EC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL3798775 | — | EC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL3798735 | — | EC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL3798531 | — | EC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL3800349 | — | EC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL3800513 | — | EC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL3800091 | — | EC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL3799501 | — | EC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL3799276 | — | EC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL3800595 | — | EC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL3798560 | — | EC50 | - | — | - | |
| CHEMBL3800122 | — | EC50 | > | 31.0 | nM | - |