Assay Detail
Binding
CHEMBL3802094
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of DRAK2 (unknown origin) using MRLC3 peptide as substrate incubated for 2 hrs by ADP-Glo kinase assay
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of indirubin derivatives as new class of DRAK2 inhibitors from high throughput screening.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 6.66 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3797480 | — | — | 1 | 8.52 |
| CHEMBL3799389 | — | — | 1 | 8.10 |
| CHEMBL3799585 | — | — | 1 | 8.00 |
| CHEMBL3799505 | — | — | 1 | 7.85 |
| CHEMBL3797466 | — | — | 1 | 7.85 |
| CHEMBL513703 | — | — | 1 | 7.68 |
| CHEMBL3798563 | — | — | 1 | 7.11 |
| CHEMBL3798680 | — | — | 1 | 6.92 |
| CHEMBL3798579 | — | — | 1 | 6.92 |
| CHEMBL3797732 | — | — | 1 | 6.70 |
| CHEMBL604263 | — | — | 1 | 6.60 |
| CHEMBL3797817 | — | — | 1 | 6.54 |
| CHEMBL3797582 | — | — | 1 | 6.48 |
| CHEMBL1077291 | — | — | 1 | 6.21 |
| CHEMBL3798736 | — | — | 1 | 6.16 |
| CHEMBL216543 | — | — | 1 | 6.15 |
| CHEMBL3799218 | — | — | 1 | 6.02 |
| CHEMBL3798747 | — | — | 1 | 5.92 |
| CHEMBL3799256 | — | — | 1 | 5.89 |
| CHEMBL3798927 | — | — | 1 | 5.89 |
| CHEMBL594192 | — | — | 1 | 5.85 |
| CHEMBL3799269 | — | — | 1 | 5.82 |
| CHEMBL3797619 | — | — | 1 | 5.50 |
| CHEMBL1083838 | — | — | 1 | 5.21 |
| CHEMBL1276127 | INDIRUBIN | 2.0 | 1 | - |
| CHEMBL1084939 | — | — | 1 | - |
| CHEMBL1077286 | — | — | 1 | - |
| CHEMBL1084938 | — | — | 1 | - |
| CHEMBL3799919 | — | — | 1 | - |
| CHEMBL3798674 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3797480 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3799389 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL3799585 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3799505 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL3797466 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL513703 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL3798563 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL3798680 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL3798579 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL3797732 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL604263 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL3797817 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL3797582 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL1077291 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL3798736 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL216543 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL3799218 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL3798747 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL3799256 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL3798927 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL594192 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL3799269 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL3797619 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL1083838 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL1276127 | INDIRUBIN | IC50 | > | 10000.0 | nM | - |
| CHEMBL1084939 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1077286 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1084938 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3799919 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3798674 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3799549 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3799765 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1095686 | — | IC50 | > | 10000.0 | nM | - |