Assay Detail
Binding
CHEMBL3806520
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to Mycobacterium tuberculosis His6-tagged CYP121 expressed in Escherichia coli C41 (DE3) cells by UV-visible spectroscopy
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mycobacterium tuberculosis |
| Cell Type | C41(DE3) |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Mycocyclosin synthase (CHEMBL1681615) ↗| Type | SINGLE PROTEIN |
| Organism | Mycobacterium tuberculosis |
Publication
Fragment-Based Approaches to the Development of Mycobacterium tuberculosis CYP121 Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 5 | 6.06 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3806115 | — | — | 1 | 7.82 |
| CHEMBL3804971 | — | — | 1 | 7.47 |
| CHEMBL3805159 | — | — | 1 | 6.54 |
| CHEMBL3806191 | — | — | 1 | 4.85 |
| CHEMBL3806237 | — | — | 1 | 3.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3806115 | — | Kd | = | 15.0 | nM | 7.82 |
| CHEMBL3804971 | — | Kd | = | 34.0 | nM | 7.47 |
| CHEMBL3805159 | — | Kd | = | 290.0 | nM | 6.54 |
| CHEMBL3806191 | — | Kd | = | 14000.0 | nM | 4.85 |
| CHEMBL3806237 | — | Kd | = | 230000.0 | nM | 3.64 |