Assay Detail
Binding
CHEMBL3806576
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Inhibition of pig kidney alanyl aminopeptidase M1 using Ala-AMC as substrate preincubated for 30 to 60 mins followed by substrate addition measured for 15 mins by spectrofluorimetric analysis
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A structural insight into the P1S1 binding mode of diaminoethylphosphonic and phosphinic acids, selective inhibitors of alanine aminopeptidases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 24 | 5.29 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3805964 | — | — | 1 | 6.30 |
| CHEMBL3805573 | — | — | 1 | 6.28 |
| CHEMBL3806197 | — | — | 1 | 6.14 |
| CHEMBL3806247 | — | — | 1 | 5.92 |
| CHEMBL3805495 | — | — | 1 | 5.83 |
| CHEMBL3805817 | — | — | 1 | 5.64 |
| CHEMBL3805288 | — | — | 1 | 5.60 |
| CHEMBL3806121 | — | — | 1 | 5.54 |
| CHEMBL3805118 | — | — | 1 | 5.49 |
| CHEMBL3805487 | — | — | 1 | 5.44 |
| CHEMBL3804856 | — | — | 1 | 5.42 |
| CHEMBL3805028 | — | — | 1 | 5.34 |
| CHEMBL3804956 | — | — | 1 | 5.27 |
| CHEMBL3805544 | — | — | 1 | 5.22 |
| CHEMBL3805193 | — | — | 1 | 5.18 |
| CHEMBL3806187 | — | — | 1 | 5.17 |
| CHEMBL3806230 | — | — | 1 | 5.16 |
| CHEMBL3805338 | — | — | 1 | 5.03 |
| CHEMBL3804861 | — | — | 1 | 4.84 |
| CHEMBL3805251 | — | — | 1 | 4.56 |
| CHEMBL3805472 | — | — | 1 | 4.54 |
| CHEMBL3806100 | — | — | 1 | 4.49 |
| CHEMBL1673064 | — | — | 1 | 4.43 |
| CHEMBL3805587 | — | — | 1 | 4.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3805964 | — | Ki | = | 500.0 | nM | 6.30 |
| CHEMBL3805573 | — | Ki | = | 520.0 | nM | 6.28 |
| CHEMBL3806197 | — | Ki | = | 723.0 | nM | 6.14 |
| CHEMBL3806247 | — | Ki | = | 1210.0 | nM | 5.92 |
| CHEMBL3805495 | — | Ki | = | 1480.0 | nM | 5.83 |
| CHEMBL3805817 | — | Ki | = | 2290.0 | nM | 5.64 |
| CHEMBL3805288 | — | Ki | = | 2490.0 | nM | 5.60 |
| CHEMBL3806121 | — | Ki | = | 2880.0 | nM | 5.54 |
| CHEMBL3805118 | — | Ki | = | 3240.0 | nM | 5.49 |
| CHEMBL3805487 | — | Ki | = | 3640.0 | nM | 5.44 |
| CHEMBL3804856 | — | Ki | = | 3830.0 | nM | 5.42 |
| CHEMBL3805028 | — | Ki | = | 4540.0 | nM | 5.34 |
| CHEMBL3804956 | — | Ki | = | 5420.0 | nM | 5.27 |
| CHEMBL3805544 | — | Ki | = | 6040.0 | nM | 5.22 |
| CHEMBL3805193 | — | Ki | = | 6580.0 | nM | 5.18 |
| CHEMBL3806187 | — | Ki | = | 6740.0 | nM | 5.17 |
| CHEMBL3806230 | — | Ki | = | 7000.0 | nM | 5.16 |
| CHEMBL3805338 | — | Ki | = | 9390.0 | nM | 5.03 |
| CHEMBL3804861 | — | Ki | = | 14500.0 | nM | 4.84 |
| CHEMBL3805251 | — | Ki | = | 27700.0 | nM | 4.56 |
| CHEMBL3805472 | — | Ki | = | 29000.0 | nM | 4.54 |
| CHEMBL3806100 | — | Ki | = | 32400.0 | nM | 4.49 |
| CHEMBL1673064 | — | Ki | = | 37100.0 | nM | 4.43 |
| CHEMBL3805587 | — | Ki | = | 94200.0 | nM | 4.03 |